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BioService Affinity HSA
Human Serum Albumin (HSA) is an abundant protein in the human body synthesized by the liver, and is highly conserved among many mammalian species (especially domain 1). With a molecular weight (MW) of approximately 66.5 kDa, HSA has many cysteine AA sites, which make it capable of binding many ligands (especially lipid-type molecules).
Sepax Technologies
Description
Albumin also transports many endogenous molecules, including hormones, fatty acids, metabolites, and other exogenous compounds, including drugs. It also buffers pH and maintains oncotic pressure.1 Therefore, HSA can greatly influence drug half-life, which is critical to pharmacokinetics and efficacy. Because of HSA’s critical role in drug transport, it is imperative and necessary to assess potential drug interactions during the development of modern therapeutics, such as Monoclonal Antibodies (mAbs). A well-controlled method to assess such immune cross-reactivity in vitro would be to immobilize HSA to a specific biocompatible resin matrix and evaluate the degree of interaction of HSA with a target mAb of interest.
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