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Proteomix AAV SAX
Adeno-associated viruses (AAV) are one of the most commonly used viral vectors for gene therapy to deliver therapeutic genes.
Sepax Technologies
Description
Quantitation of empty and full AAV capsids is critical to understand and ensure the product quality, safety, and potential efficacy. Multiple techniques have been used in this application however all have some shortcomings and challenges:
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Features
Specifications
- Improving Separation of Empty and Full AAV Capsids: Achieved higher resolution separation of full capsids from empty capsids, allowing for full separation and more accurate molecular weight calculations in the applications.
- Easy Linear Salt Gradient for User Friendly Method Development: An easy linear salt gradient method was used as an excellent starting point for method development and provided a user-friendly and flexible approach for developing analytical methods across a variety of AAV samples.
- MALS Compatibility with Low Shedding and Accuracy: AEX-MALS method was employed in the application for accurate quantitation of empty and full capsids with low shedding and baseline noise.
- Monosized Base Beads: Precision-engineered monosized base beads provide excellent higher resolving power and improved column packing and lot- to-lot reproducibility for consistent and reliable performance techniques.
- Low Pressure with High Pressure Limit for Fast Run: The beads have low pressure with a high-pressure limit, enabling up to 1 mL/min high throughput fast assay.
- Robust Lot-to-Lot Consistency: AAV8 sample combined with UV-MALS with stringent specification for batch quality control ensures robust lot-to-lot consistency for product release.
- UPLC and HPLC Compatible: This 3 µm HPLC column is compatible with both UPLC and HPLC use which enables easy adaptability for method transfers applied across a diverse range of applications, maximizing both performance and efficiency.
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