Sepax Technologies

USA based leading chromatography product manufacturer and service provider specializing in biological separation areas.

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List of Products from this Brand

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HP-Cyano

HP-Cyano
Synthesized with monomeric and fully endcapped chemistry, HP-Cyano phase is bonded with propylcyano functional group that allows special interaction with polar compounds. The monomeric bonding chemistry enables high efficiency and high resolution separation of peptide, proteins, acidic, neutral and basic organic compound, and pharmaceuticals.
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HP-Diol

Synthesized with polymeric chemistry, HP-Diol phase is bonded with 1,2-dihydroxypropyl propyl ether functional group that allows special interaction with polar compounds
The polymeric bonding chemistry enables high efficiency and high stability separation of polar pharmaceuticals, peptide, and proteins. HP-Diol phase can also be used as size exclusion separation of biological molecules.
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HP-SAX(II)

HP-SAX(II) is a silica based mixed mode strong anion exchange phase.
The phase has a mixed chemical structure of quaternary ammonium and phenyl group. The mixed mode of strong anion exchange and hydrophobicity offers unique selectivity and high resolution separation for various organic compounds such as aromatic or aliphatic carboxylic acids and sulfonic acid. The uniform polymeric bonding of HP-SAX(II) enhances its stability under various separation conditions. HP-SAX(II) columns typical application areas include pesticides, herbicides, pharmaceuticals, inorganic anions and biological samples such as nucleotides and sugars. It can be operated under a variety of mobile phases, organic solvents including water and organic solvents mixture (such as methanol and acetonitrile), as well as buffer liquid such as phosphate.
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HP-SCX

HP-SCX is a silica based mixed-mode strong cation exchange phase. The phase has a mixed chemical structure of sulfonic acid and phenyl group.
The mixed mode of strong cation-exchange and hydrophobicity offers unique selectivity and high resolution separation for cationic/basic and nitrogen containing compounds as well as desirable retention for a variety of weak cationic and neutral organic compounds. The uniform polymeric bonding of HP-SCX enhances its stability under various separation conditions.
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HP-Silica

HP-Silica phase is made of activated hydroxyl (-OH) functional group with the pore size selection of 60, 120, 200, 300, 500, 1000 and 2000 Å and particle size selection of 1.8, 3, 5, and 10 µm.
Carbon loading is 0.0%. HP-Silica is used as the normal phase as well as HILIC phase. HP-Silica phases are suitable for separations of polar and basic organic compounds, such as vitamins, steroids, as well as pharmaceuticals.
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Mono GPC

Mono GPC resin is designed for high resolution separation of synthetic polymers.
The porous resin is made of highly cross-linked polystyrene divinylbenzene (PS/DVB) polymer with narrow-dispersed particle distribution. The uniformed pore size distribution provides accurate linear relationship between the retention time and molecular weight during the separation. Highly cross-linked porous PS/DVB also provides excellent chemical and physical stability, so the molecular weight calibration curve and column efficiency show minimum change with different organic solvents. With large pore volume, Mono GPC resin offers high resolution for polymer separation. Mono GPC resin is available with single pore size or multi pore sizes mixture.
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Monomix dT20 Affinity

Sepax Monomix dT20 Affinity Resin is a narrowly dispersed polymethacrylate rigid base bead, functionalized with a polyhydroxylated surface coating layer that provides a bio-inert surface, which shows low non-specific binding. Oligo dT20-mer is then conjugated to the bead surface through a proprietary method.
The resulting affinity resin is specially designed and highly optimized for the isolation of messenger RNA (mRNA). Most mRNA molecules contain a tail of poly(adenylic acid) (polyA tail), up to 250 bases in length. The Monomix dT20 Affinity Resin surface allows capture of mRNA through base pairing between oligo dT20-mer and the mRNA polyA tail using a simple and convenient chromatography procedure.
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Monomix H2P SAX

Monomix H2P-SAX columns are designed to effectively quantify neutral amphiphilic surfactants, such as Tween 80, Tween 20, and Poloxamers, which are commonly present in formulated biological samples, such as Monoclonal Antibodies.
The rigid and spherical solid support of the resin is composed of highly cross-linked poly(styrene/divinylbenzene/modifier) (PS/DVB/M). The average particle size is 40 µm, with a narrow size distribution (D90/D10 < 1.3), and ideal porous structure and robust chemical/physical stability. The polymeric porous beads are further covalently modified with mixed-mode ligands so that the beads are water wettable, and at the same time can absorb amphiphilic surfactants.
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Monomix MC10-SEC

Monomix MC10 SEC columns are packed with highly crosslinked, rigid, spherical polymethacrylate-based particles engineered for high-performance size exclusion chromatography.
With a narrow particle-size distribution, 10 µm particle size, and pore size options of 500, 1000, and 3000 Å, these columns support efficient separation across a wide range of biomolecular sizes. Proprietary hydrophilic surface chemistry minimizes nonspecific interactions between the sample and the stationary phase, helping to improve recovery, reduce secondary interactions, and maintain more reliable size-based separations. The uniform, smooth, and highly spherical particle architecture contributes to low backpressure, high column efficiency, and consistent column performance. Monomix MC10 SEC columns offer broad pH tolerance (2-12), elevated temperature stability up to 80 °C, and operating pressures up to 10 bar for demanding SEC workflows.
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